Data
Official data in SubjectManager for the following academic year: 2023-2024
Course director
-
Dr. Edina PANDUR
assistant professor,
Department of Pharmaceutical Biology -
Number of hours/semester
lectures: 0 hours
practices: 0 hours
seminars: 14 hours
total of: 14 hours
Subject data
- Code of subject: OAF-VAA-T
- 1 kredit
- General Medicine
- Optional modul
- spring
OAA-MB2-T completed
Course headcount limitations
min. 4 – max. 24
Available as Campus course for 10 fő számára. Campus-karok: ETK GYTK TTK
Topic
During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over. During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.
Lectures
Practices
Seminars
- 1. Solution chemistry of iron, interactions with other metal ions.
- 2. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
- 3. Microbial Iron Transport and Metabolism
- 4. Iron uptake by yeasts
- 5. Cellular Iron Uptake and Export in Mammals: iron transporters
- 6. Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin
- 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis
- 8. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive elements and iron regulatory proteins
- 9. Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance
- 10. Pathophysiology of Iron Deficiency: anemias, thalassemias
- 11. Iron disorders and Laboratory parameters
- 12. Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system
- 13. Brain iron metabolism, the role of iron in neurodegenerative diseases
- 14. Pathophysiology of Iron overload: hemochromatosis
Reading material
Obligatory literature
Literature developed by the Department
The educational materials will be uploaded to Neptune MeetStreet
Notes
Recommended literature
Robert Crichton: Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Conditions for acceptance of the semester
Max. 3 absences
Mid-term exams
Three tests with one possible retake.
Making up for missed classes
Personal consultation
Exam topics/questions
Simple choice test based on the seminars.
Examiners
Instructor / tutor of practices and seminars
- Dr. Pandur Edina
- Jánosa Gergely
- Pap Ramóna