Genetic Background of Gene Manipulation I

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2023-2024

Tematika

The subject introduces the basics of genetics and the basic principles of inheritance (e.g. Mendelian and non-Mendelian inheritance, sex-linked inheritance, etc.). During the course, the properties, methodologies, and statistical background of linkage studies are discussed (e.g. allele frequency, Hardy-Weinberg equilibrium, etc.). The course describes the characteristics, structure, and variations of the genome of the important model animals used in biotechnology. The course gives an overview of the molecular mechanism and regulation of gene expression in prokaryotes and eukaryotes. The course presents the basic technologies applied in genetics; during the practice, students will become familiar with these methods.

Előadások

• 1. Introduction: Concepts of Genetics - Dr. Pongrácz Judit Erzsébet
• 2. Mitosis and meiosis I. - Dr. Pongrácz Judit Erzsébet
• 3. Mitosis and meiozis II. - Dr. Pongrácz Judit Erzsébet
• 4. Mendelian principles I - Dr. Pongrácz Judit Erzsébet
• 5. Mendelian principles II - Dr. Pongrácz Judit Erzsébet
• 6. Mendelian genetics - Dr. Pongrácz Judit Erzsébet
• 7. Independent assortment - Garai Kitti
• 8. Laws of probability - Garai Kitti
• 9. Patterns of inheritance - Garai Kitti
• 10. Extension of Mendelian genetics - alleles and sex lined inheritance - Dr. Pongrácz Judit Erzsébet
• 11. Chromosome mapping in Eukaryotes I. - Dr. Pongrácz Judit Erzsébet
• 12. Chromosome mapping in Eukaryotes II. - Dr. Pongrácz Judit Erzsébet
• 13. Genetic analysis and mapping in Bacteria and bacteriophages I. - Garai Kitti
• 14. Genetic analysis and mapping in Bacteria and bacteriophages II. - Garai Kitti
• 15. Sex determination and sex chromosomes - Garai Kitti
• 16. Chromosomal mutations I. - Dr. Pongrácz Judit Erzsébet
• 17. Chromosomal mutations II. - Dr. Pongrácz Judit Erzsébet
• 18. Extracellular inheritance - Dr. Pongrácz Judit Erzsébet
• 19. DNA structure, organization, replication and analysis I. - Garai Kitti
• 20. DNA structure, organization, replication and analysis II. - Garai Kitti
• 21. DNA replication and recombination I. - Garai Kitti
• 22. DNA replication and recombination II. - Garai Kitti
• 23. DNA organization in chromosomes I. - Garai Kitti
• 24. DNA organization in chromosomes II. - Garai Kitti
• 25. Genetic code and transcription - Garai Kitti
• 26. Genetic code and transcription II. - Garai Kitti
• 27. Translation and proteins I. - Dr. Pongrácz Judit Erzsébet
• 28. Translation and proteins II. - Dr. Pongrácz Judit Erzsébet

Gyakorlatok

• 1. Exploring genomics I.
• 2. Exploring genomics II.
• 3. Independent assortment I.
• 4. Independent assortment II.
• 5. Laws of probability I.
• 6. Laws of probability II.
• 7. Laws of probability III.
• 8. Chi-Square analysis I.
• 9. Chi-Square analysis II.
• 10. Chi-Square analysis III.
• 11. Mendelian inheritance in man - test or not to test
• 12. Modern approaches to understanding gene function
• 13. Genetic background and phenotype I.
• 14. Genetic background and phenotype II.
• 15. Environmental effects on genetic background and phenotype I.
• 16. Environmental effects on genetic background and phenotype II.
• 17. Environmental effects on genetic background and phenotype III.
• 18. Environmental effects on genetic background and phenotype IV.
• 19. Human chromosome maps and diseases I.
• 20. Human chromosome maps and diseases II.
• 21. Human chromosome maps and diseases III.
• 22. Human chromosome maps and diseases IV.
• 23. Multidrug resistance in bacteria I.
• 24. Human chromosome maps and diseases II.
• 25. Modern approaches to understanding gene function - Drosophila I.
• 26. Modern approaches to understanding gene function - Drosophila II.
• 27. Gene expression - RNA and protein I.
• 28. Gene expression - RNA and protein II.

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Lecture ppt-s and seminar material based on the recommended literature

Jegyzet

Ajánlott irodalom

Klug et al. - Concepts of Genetics 12th Edition
Benjamin A. Pierce - Genetics_ A Conceptual Approach 7th Edition (2020)

A félév elfogadásának feltételei

Maximum of 15 % absence allowed

Félévközi ellenőrzések

One midterm test on the 6th week of the semester. If failed, two additional opportunities are provided for the students. The test is accepted if the student reached 51% on the test.

Távolmaradás pótlásának lehetőségei

Not possible

Vizsgakérdések

Exam topics will be available on Teams and cover the topic list.

Vizsgáztatók

• Ádám Zoltán Mihály
• Dr. Pongrácz Judit Erzsébet
• Garai Kitti

Gyakorlatok, szemináriumok oktatói

• Ádám Zoltán Mihály
• Garai Kitti