Pharmaceutical Applied Immunology

Data

Official data in SubjectManager for the following academic year: 2023-2024

Topic

Pharmacist perspective on pharmaceutical products that affect the immune system or function in an immunological manner. The course describes the immunological effect and mechanism of action for various pharmaceutical products (both conventional small molecules and modern macromolecules) with special attention to drugs with direct immune-modulation or sharing common immunological side-effects. The course details which products and drug combinations lead to efficient immune-mediated disease resolution or the development of adverse side-effects due to affecting the immune system. The course also discusses the way drug combinations affect the immune system.

Lectures

• 1. Pharmaceutical products acting on the immune system from a pharmacist perspectiv, course structure, obligations - Dr. Kvell Krisztián
• 2. Production of antibody-based products, identification of their products - Dr. Kvell Krisztián
• 3. Modification of antibody-based products – fusion, labeling, radioactive and toxic antibodies - Dr. Kvell Krisztián
• 4. Utilization of monoclonal antibodies in cancer therapy – products acting directly on cancer cells or the tumor micro-environment - Dr. Kvell Krisztián
• 5. Modulation of the immune response through monoclonal antibodies in autoimmune inflammatory diseases - Dr. Kvell Krisztián
• 6. Production of pharmaceutically relevant cytokines, chemokines and their receptors - Dr. Kvell Krisztián
• 7. Modulation of immune response in malignant diseases through the use of cytokines - Dr. Kvell Krisztián
• 8. Modulation of immune response in autoimmune diseases through the use of cytokines - Dr. Kvell Krisztián
• 9. The effect of non-steroid anti-inflammatory drugs on immune cells and molecular processes - Dr. Kvell Krisztián
• 10. The effect of steroid anti-inflammatory drugs on immune cells and molecular processes - Dr. Kvell Krisztián
• 11. The effect of cytostatic drugs on immune cells and molecular processes - Dr. Kvell Krisztián
• 12. The effect of various conventional and modern vaccines on immune cells - Dr. Kvell Krisztián
• 13. The role of certain vitamins (B, C, D, E) in the prevention and therapy of immune-pathologies - Dr. Kvell Krisztián
• 14. The role of certain trace elements (copper, zinc, selenium) in the prevention and therapy of immune-pathologies - Dr. Kvell Krisztián

Practices

Seminars

• 1. Quick-test: Covid test
• 2. Quick-test: pregnancy test
• 3. Immunoglobulin therapy: IVIG collection, donor validation, pooling
• 4. Immunoglobulin therapy: IVIG application in certain diseases
• 5. Determination of blood groups with various methods
• 6. Hemopoietic drugs: mechanism of action, application
• 7. Midterm consultation seminar
• 8. Arthritis treatment using small molecule-based immune therapy (NSAID, steroid)
• 9. Arthritis treatment using macromolecule-based immune therapy (anti-IL6)
• 10. Arthritis treatment using small molecule-based immune therapy (5-ASA)
• 11. Arthritis treatment using macromolecule-based immune therapy (anti-TNFalpha)
• 12. Immune-checkpoint therapy (CTLA4, PD1), machanism of action, side effects
• 13. Immune-checkpoint therapy (CTLA4, PD1) in certain malignant diseases
• 14. Final consultation seminar

Reading material

Obligatory literature

Literature developed by the Department

Lecture and seminar ppt

Notes

Lecture notes, learning materials of the lectures are available on MeetStreet, Moodle
Pharmaceutical Applied Immunology 2019

Recommended literature

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written test

Making up for missed classes

According to the Code of Studies and Examinations.

Exam topics/questions

MeetStreet, Teams, Moodle

Examiners

• Dr. Bánfai Krisztina
• Dr. Kvell Krisztián

Instructor / tutor of practices and seminars

• Bóvári-Biri Judit
• Dr. Bánfai Krisztina
• Dr. Kvell Krisztián